Mechanisms of Cardiac Repair and Regeneration

February 18, 2019

Cardiovascular regenerative therapies are pursued on both basic and translational levels. Although efficacy and value of cell therapy for myocardial regeneration can be debated, there is a consensus that profound deficits in mechanistic understanding limit advances, optimization, and implementation. In collaboration with the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes), this review overviews several pivotal aspects of biological processes impinging on cardiac maintenance, repair, and regeneration. The goal of summarizing current mechanistic understanding is to prompt innovative directions for fundamental studies delineating cellular reparative and regenerative processes. Empowering myocardial regenerative interventions, whether dependent on endogenous processes or exogenously delivered repair agents, ultimately depends on mastering mechanisms and novel strategies that take advantage of rather than being limited by inherent myocardial biology.

 

Find more about this article written by members of the TACTICS alliance in the Circulation Research website: 10.1161/CIRCRESAHA.117.312586

Please reload

Last Entries
Please reload

Archive
Please reload

Tags

I'm busy working on my blog posts. Watch this space!

Please reload

2016 Tactics. Proudly created with Wix.com